Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease
Identifieur interne : 000146 ( Main/Exploration ); précédent : 000145; suivant : 000147Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease
Auteurs : Hélène Mollion [France] ; Peter Ford Dominey [France] ; Emmanuel Broussolle [France] ; Jocelyne Ventre-Dominey [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
English descriptors
- KwdEn :
Abstract
Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23769
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title><author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name></author><author><name sortKey="Dominey, Peter Ford" sort="Dominey, Peter Ford" uniqKey="Dominey P" first="Peter Ford" last="Dominey">Peter Ford Dominey</name></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Ventre Ominey, Jocelyne" sort="Ventre Ominey, Jocelyne" uniqKey="Ventre Ominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:346192D8FA7FD958C858317FE5152B218F0891D8</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23769</idno><idno type="url">https://api.istex.fr/document/346192D8FA7FD958C858317FE5152B218F0891D8/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000440</idno><idno type="wicri:Area/Main/Curation">000380</idno><idno type="wicri:Area/Main/Exploration">000146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title><author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dominey, Peter Ford" sort="Dominey, Peter Ford" uniqKey="Dominey P" first="Peter Ford" last="Dominey">Peter Ford Dominey</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurology Unit, Pierre Wertheimer Neurology Hospital, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Ventre Ominey, Jocelyne" sort="Ventre Ominey, Jocelyne" uniqKey="Ventre Ominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2019">2019</biblScope><biblScope unit="page" to="2025">2025</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">346192D8FA7FD958C858317FE5152B218F0891D8</idno><idno type="DOI">10.1002/mds.23769</idno><idno type="ArticleID">MDS23769</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>functional dissociation</term><term>motor execution</term><term>subthalamic nucleus stimulation</term><term>visual memory</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Lyon</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name></noRegion><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><name sortKey="Dominey, Peter Ford" sort="Dominey, Peter Ford" uniqKey="Dominey P" first="Peter Ford" last="Dominey">Peter Ford Dominey</name><name sortKey="Ventre Ominey, Jocelyne" sort="Ventre Ominey, Jocelyne" uniqKey="Ventre Ominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000146 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000146 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:346192D8FA7FD958C858317FE5152B218F0891D8
|texte= Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |